What is Lipase and Why Do We Use Them?

Understanding Lipase

Lipase is a crucial digestive enzyme that plays a significant role in the breakdown of fats within your body. The pancreas, situated behind the lower stomach, produces the majority of lipase. Additionally, lipase is also secreted by salivary glands and the stomach.

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While it’s typical to find small amounts of lipase in your bloodstream, elevated levels may indicate pancreatic issues, such as pancreatitis or certain pancreatic diseases. Consequently, lipase tests are vital for diagnosing these disorders.

Other names include: serum lipase, lipase, LPS.

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Generally, most individuals do not require additional lipase. However, certain conditions may benefit from lipase supplementation.

Celiac Disease

Celiac disease occurs when gluten—a protein present in grains—affects the intestine adversely. Common symptoms include abdominal discomfort, bloating, weight loss, and fatigue. Patients must adhere to a strict gluten-free diet. Research involving pancreatic enzymes as a treatment for celiac disease has been undertaken, although the extent of their effectiveness remains uncertain. For instance, a study with 40 children found that those receiving pancreatic enzyme therapy, including lipase, demonstrated modest weight gain in comparison to a placebo group. Notably, this weight gain was evident within the first month, but subsequent treatment did not yield further improvements.

Indigestion

A small-scale clinical study with 18 participants indicated that supplements containing lipase alongside other pancreatic enzymes could alleviate bloating, gas, and feelings of fullness after consuming a high-fat meal. These symptoms are often linked to irritable bowel syndrome (IBS), leading some researchers to suggest the potential benefits of pancreatic enzymes in managing IBS symptoms, though no conclusive studies have validated this hypothesis.

Cystic Fibrosis

Cystic fibrosis is a genetic disorder characterized by the production of thick, sticky mucus, hindering the release of pancreatic enzymes that aid in nutrient absorption. To help mitigate nutritional deficiencies, healthcare professionals may prescribe pancreatic enzyme supplementation to assist patients in deriving maximum nutrition from their food.