Similarities and differences in hepatitis B and C virus ...

Hepatocellular carcinoma (HCC), the major manifestation of primary liver cancer, is one of the most frequent and malignant diseases worldwide. Among other environmental factors, hepatitis viruses, as the hepatitis B (HBV) and hepatitis C (HCV) viruses, are to be listed in the etiology of HCC. Both of these viruses cause a wide spectrum of clinical manifestations, ranging from healthy carrier state to acute and chronic hepatitis, cirrhosis and HCC. HBV and HCV are different viruses in structure: HBV contains a DNA genome which replicates through an RNA intermediate and requires an active viral reverse transcriptase (RT) polymerase enzyme, while HCV is an RNA virus which has no RT activity and replicates on the cellular membrane by RNA replication. In this review we discuss how these two biologically diverse viruses use common pathways to induce hepatocarcinogenesis despite their significant structural and viral cycle differences. A summary is also given of several observable common and different features. Direct integration of HBV viral sequences into the host genome increases the genomic instability, which does not occur in HCV infection. However, viral proteins may directly play a significant role in the induction of carcinogenesis by both viruses.

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Hepatitis B and hepatitis C are different types of virus that damage your liver. They both spread through blood. But people get these two types of viruses in different ways. The treatment for them varies too.

Hepatitis B spreads through blood and some body fluids. Most people get hepatitis B at birth or in early childhood. You can also get hepatitis B if you have sex without a condom or have unsafe medical procedures. There is a vaccine for hepatitis B, but you can't get rid of it completely. There is treatment that works really well. This lowers the amount of damage to your liver.

Hepatitis C spreads through the blood. Most people in Australia get hepatitis C by taking drugs with a needle. But you can also get it by getting a tattoo by someone who is not a proper tattoo artist. You can get it as well through unsafe medical procedures and vaccination programs, or anal sex without a condom. There is no vaccine for hepatitis C. But there are medicines that work well to get rid of it.

Both hepatitis B and hepatitis C can lead to cirrhosis (scarring of the liver), liver disease and liver cancer.

Find out more about hepatitis B

If you are looking for more details, kindly visit hbsag hcv.

Find out more about hepatitis C

References

Hepatitis B, All Good, ASHM

Hepatitis C, All Good, ASHM

Updated 14 March

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